Polyzene-F Makes the Difference

PzF, Thromboresistance, and Endothelialization

PzF is a thin-film polymer coating technology used to modify the blood-contacting surface of medical devices. In cardiovascular device applications, PzF-coated stent technologies have been associated with thromboresistance, reduced inflammatory response, and accelerated endothelialization compared with certain drug-eluting stent platforms. The relevance of these findings should be evaluated for each new device, material, geometry, and intended use.

“I believe Polyzene-F will continue to play an important role in delivering safety and efficacy in clinical practice.”
— Aloke Finn, MD, Medical Director and Chief Scientific Officer at CVPath and Associate Professor of Medicine at the University of Maryland

The Future of Medical Device Implants

Alta Biomed develops and manufactures novel surface coated technologies including its proprietary Polyzene-F nanocoating and COBRA SG Drug-Coated PTCA Balloon technology. This next-generation innovation is transforming clinical practice and promoting positive outcomes in patients around the world.

Polyzene-F™ NanoCoating A Legacy of Safety

Now, for the first time ever, medical device manufacturers seeking to optimize implant interaction within the body can partner with Alta Biomed to apply the revolutionary PzF nanocoating to their technology.

Our revolutionary drug-free polymer, Polyzene-F (PzF), is imparted with the following unique properties observed in pre-clinical studies:

  • Anti-thrombogenic

  • Anti-inflammatory

  • Rapid & complete healing*1-5

 Powerful Passivation & Pro-Healing* Technology

Diagram illustrating the properties of a stent embedded in tissue. It shows polyzene-F and albumin on the surface, promoting anti-thrombotic and anti-inflammatory qualities. Endothelial and progenitor cells interact with the stent for healing and thrombosis resistance.

Polyzene-F™ (“PzF”) is a nano-thin biomimetic surface coating that acts as a barrier between the device, intimal surface and circulating elements in the blood.

Thrombo-Resistance

SEM image of platelet adherence to PzF coating

Fewer platelets adhere to PzF Nanocoating1-3,6

Anti-Inflammatory

Significantly Lower Vessel Injury with COBRA PzF Stent 1-5

ComparatiCOve histology micrographs of arterial sections with BRA-PzF and Vision BMS stents at various time intervals, including 5 days, 28 days (single and overlap), and 90 days, showing tissue response and stent coverage.

Less Inflammation, Neointimal thickness, area, and struts with granuloma.

View PzF Publications
View PzF Publications
“Polyzene-F has the potential to significantly limit a wide range of implant complications.”
— Professor Dr. Michael Grunze, Ruprecht-Karls-University in Heidelberg, Co-inventor of Polyzene-F

History of Commercial Success

Cardiology - COBRA PzF NanoCoated Coronary Stent (NCS)

Illustration of a PzF coated stent with molecular structures attached

PzF nanocoated, non drug-eluting coronary stent allows physicians to safely and effectively treat patients with short 1-month DAPT.1

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Oncology/Radiology - Embozene™ Microspheres

CeloNova Biosciences embolization microspheres in various colors, arranged in transparent tubes.

PzF nanocoated spheres are designed to be virtually “invisible” to the body, reducing inflammation and unwanted tissue reaction.

Acquired by Boston Scientific in 2015. Read Press Release.

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Oncology/Drug Elution - Tandem™ Microspheres

Tandem logo and syringe with text "Efficiency | Precision | Flexibility"

PzF nanocoated spheres are designed to be virtually “invisible” to the body, reducing inflammation and unwanted tissue reaction.

Acquired by Boston Scientific in 2015. Read Press Release.

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Learn more

On-Demand Webinars

Understanding the Science Behind COBRA PzF NCS: A New Category of Stent

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Cardiac Injury and PCI in the Era of COVID-19

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View Webinar

Applications

PzF coating may be considered for vascular and blood-contacting technologies such as:

  • Bare metal stents

  • Covered stents

  • Vascular grafts

  • ePTFE grafts

  • PET / polyester graft materials

  • Structural Heart

  • Catheter-based vascular devices

  • Blood filters

  • Embolic protection devices

Applications
Applications

  • Thrombectomy devices

  • Vascular access devices

  • Anastomosis devices

  • Implantable blood-contacting components

  • PICCs

  • LVADs

  • Can load and elute drugs

  • Anti-stick coating

Material Compatibility

PzF coating feasibility can be evaluated on a range of medical device materials, including:

  • Nitinol

  • Stainless Steel

  • Cobalt chromium

  • PET/polyester

  • ePTFE and PTFE-based materials

  • Polyurethane, TPU, PCU

  • Silicone

  • Pebax and catheter polymers

  • Polycarbonate and other engineering polymers

 * AS DEMONSTRATED IN PRECLINICAL STUDIES.

Correlation between bench testing, animal studies and humans have not been determined.

  1. Koppara T, Sakakura K, Pacheco E, et al. Preclinical evaluation of a novel polyphosphazene surface modified stent. International Journal of Cardiology. 2016; 222:217-225.

  2. Mrowietz C, Franke R, Seyfert U, et al. Haemocompatibility of polymer-coated stainless steel stents as compared to uncoated stents. Clinical Hemorheology and Microcirculation. 2005; 32:89–103.

  3. Richter G, Stampfl U, Stampfl S, et al. A New Polymer Concept for Coating of Vascular Stents Using PTFEP (poly(bis(trifluoroethoxy)phosphazene) to Reduce Thrombogenicity and Late In-Stent Stenosis. Investigative Radiology. 2005; 40(4):210-218.

  4. Radeleff B, Thierjung H, Stampfl U, et al. Restenosis of the CYPER-Select, TAXUS-Express, and Polyzene-F NanoCoated Cobalt-Chromium Stents in the Minipig Coronary Artery Model. Cardiovasc Intervent Radiol. 2007

  5. Jinnouchi, H, Mori H, et al. Thromboresistance and Functional Healing in the COBRA PzF Stent versus Competitor DES: Implications for Dual Anti-Platelet Therapy. EuroIntervention. 2018 Oct. Online ahead of print.