PzF Antithrombotic Coatings for Blood-Contacting Medical Devices
Alta Biomed helps medical device companies evaluate, develop, and test PzF thin-film antithrombotic coatings for vascular and other blood-contacting devices.
Surface Technology for Blood-Contacting Devices
Blood-contacting medical devices require careful attention to surface chemistry, coating integrity, particulate risk, and hemocompatibility. Alta Biomed supports medical device developers with PzF coating technology and testing services designed for vascular, catheter-based, implantable, and other blood-contacting applications.
Our work helps customers evaluate whether PzF surface modification is feasible for their device, how the coating performs after handling or simulated use, and how coated and uncoated devices compare in development-stage blood-contacting test models.
Polyzene-F NanoCoating
Distinct froPolyzene-F, also known as PzF, is Alta Biomed’s thin-film polymer coating technology for medical device surface modification. PzF can be evaluated on a range of vascular and blood-contacting devices where surface chemistry, thrombus formation, coating integrity, and hemocompatibility are important development considerations.
PzF coating programs are device-specific and may include surface preparation, coating application, coating inspection, simulated use evaluation, acute particulate testing, and coated vs. uncoated human blood loop testing.
Our Services
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Medical Device Coating Services
PzF thin-film coating feasibility and process development for vascular and blood-contacting medical devices, including stents, grafts, catheters, filters, and implantable components.
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Hemocompatibility Testing
Dynamic human blood loop testing to compare coated and uncoated devices, evaluate blood-material interactions, and support ISO 10993-4-aligned development programs.
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Particulate Testing
Coating inspection, simulated use evaluation, microscopy, and acute particulate testing support for coated and blood-contacting medical devices.
Applications
Alta Biomed supports PzF coating feasibility for vascular and blood-contacting medical devices across a range of materials, geometries, and development stages.
Application areas include:
Bare metal stents
Covered stents
Vascular grafts
ePTFE grafts
PET / polyester graft materials
Structural Heart
Catheter-based vascular devices
Blood filters
Embolic protection devices
Thrombectomy devices
Vascular access devices
Anastomosis devices
Implantable blood-contacting components
PICCs
LVADs
Can load and elute drugs
Anti-stick coating
History of Commercial Success
Cardiology - COBRA PzF NanoCoated Coronary Stent (NCS)
PzF nanocoated, non drug-eluting coronary stent allows physicians to safely and effectively treat patients with short 1-month DAPT.1
Oncology/Radiology - Embozene™ Microspheres
PzF nanocoated spheres are designed to be virtually “invisible” to the body, reducing inflammation and unwanted tissue reaction.
Product acquired by Boston Scientific in 2015. Read Press Release.
Oncology/Drug Elution - Tandem™ Microspheres
Embozene TANDEM® Microspheres are spherical, tightly calibrated, biocompatible, non-resorbable, hydrogel microspheres coated with an inorganic perfluorinated polymer (Polyzene®-F). They are available in a range of sizes suitable for embolic therapy.
Acquired by Boston Scientific in 2015. Read Press Release.
Levine G, Bates E, Bittl J, et al. 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients with Coronary Artery Disease. Circulation. 2016;134(10):e123-55.
Xero-Gel Drug-Coated PTCA Balloon
The novel Xero-Gel Drug-Coated PTCA Balloon with bioactive medical coating is designed to optimize non-proliferative drug delivery to address small vessel stenosis, restenosis and bifurcations.
Partnership & Co-Development Opportunities
Now, for the first time ever, Alta Biomed is bringing their unique, proprietary surface coatings to the broader market, creating partnership opportunities and co-development opportunities with medical device manufacturers seeking to optimize their medical device performance.
Have a vascular, catheter-based, implantable, or other blood-contacting medical device that may benefit from PzF surface modification?
Alta Biomed can support coating feasibility, process development, coating integrity evaluation, acute particulate testing, and hemocompatibility testing.